Scientists look at anti-cancer ability of compound in great burnet herb used in Chinese Medicine

(Natural News) The flowering plant scientifically known as Sanguisorba officinalis (great burnet) is a common Chinese herbal medicine used to stop bleeding and reduce inflammation. Research suggests that it has great therapeutic potential due to its broad range of biological properties, which include anti-inflammatory, antioxidant and anti-cancer properties.
In a recent study published in the journal Chinese Medicine, Chinese researchers explored the molecular mechanism behind great burnet’s anti-cancer activity against colorectal cancer cells. They found that one of its active components can stop the Wnt/B-catenin signaling pathway, which is involved in cell proliferation and self-renewal. When dysregulated, this pathway contributes to the development of diseases like colorectal cancer.
A compound in great burnet targets genes involved in cancer
To investigate the ability of great burnet to inhibit the growth of cancer cells, the researchers first extracted one of its main bioactive compounds, 1,4,6-Tri-O-galloyl-B-D-glucopyranose (TGG). TGG is classified as a tannin, an organic subtance with astringent properties often found in the galls and barks of various plants. They tested the anti-cancer activities of TGG by treating mouse embryonic fibroblasts (NIH3T3) and human colon adenocarcinoma cells (HT29) with it.
Using different assays and biochemical techniques, the researchers measured the …

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